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US: The Sun

Found: Mon Jun 19 03:31:34 2017 PDT
Source: Sun, The (UK)
Copyright: 2017 News Group Newspapers Ltd
Contact: letters@the-sun.co.uk
Website: http://www.thesun.co.uk/
Details: http://www.mapinc.org/media/433
Webpage: https://www.thesun.co.uk/living/3830876/ne... [translate]
Author: Andrea Downey, Digital, Health Reporter, tips@the-sun.co
Newshawk: http://drugpolicycentral.com/bot/


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The Sun New 3-in-1 blood test could provide personalised treatment for patients with advanced prostate cancerJump directly to the content

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CANCER TEST

New 3-in-1 blood test could provide personalised treatment for patients with advanced prostate cancer

The new tests is able to identify men with gene mutations associated with the disease, check who is responding to treatment and monitor if the cancer is becoming drug resistant

By Andrea Downey, Digital Health Reporter

19th June 2017, 9:51 am

Updated: 19th June 2017, 9:56 am

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A NEW three-in-one blood test could pave the way for personalised treatment for advanced prostate cancer, say scientists.

The test targets specific gene mutations associated with the disease.

Getty Images

3 The test can check for cancer DNA mutations and also monitor how fast treatment is working

By looking for cancer DNA in blood samples, researchers were able to identify men with defective BRCA genes who were likely to benefit from drugs called PARP inhibitors.

The test can also be used to monitor DNA in the blood after treatment had started, allowing patients who were not responding quickly to be switched to alternative treatments.

The same test was also used to pick up signs of evolving cancer showing the first signs of drug resistance.

Professor Johann de Bono, who led the team at The Institute of Cancer Research in London, said: "We think it could be used to make clinical decisions about whether a PARP inhibitor is working within as little as four to eight weeks of starting therapy.

"Not only could the test have a major impact on treatment of prostate cancer, but it could also be adapted to open up the possibility of precision medicine to patients with other types of cancer as well."

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More than 40,000 men in the UK are diagnosed with prostate cancer every year, making it the most common male cancer.

Around 11,000 die from the disease, which is often localised, slow-growing, and relatively simple to treat.

The test could see a PARP inhibitor, called olaparib, become a standard treatment for advanced prostate cancer.

PARP inhibitors such as olaparib block an enzyme used by cancer cells with defective BRCA 1 and 2 genes to repair their DNA.

When this enzyme is blocked the cells die.

While some patients respond to the drugs for years, others either fail to respond at an early stage or develop resistant cancer.

Getty Images

3 More than 40,000 men in the UK are diagnosed with prostate cancer every year

The new test, reported in the journal Cancer Discovery, was developed with the help of 49 patients enrolled in a clinical trial investigating the effectiveness of olaparib.

Cancer DNA dropped by almost half in men who were responding to the drug.

These patients survived and average of 17 months compared with 10 months for those whose cancer DNA levels remained high.

Professor Paul Workman, chief executive of the Institute of Cancer Research, said: "Blood tests for cancer promise to be truly revolutionary.

"They are cheap and simple to use, but most importantly, because they aren't invasive, they can be employed or applied to routinely monitor patients to spot early if treatment is failing -- offering patients the best chance of surviving their disease.

Getty Images

3 Scientists hope the new test will pave the way for more personalised treatment for advanced prostate cancer patients

"This test is particularly exciting because it is multi-purpose, designed for use both before and after treatment, and using both the absolute amounts of cancer DNA in the bloodstream and also a readout of the specific mutations within that genetic material."

Dr Matthew Hobbs, deputy director of research at the charity Prostate Cancer UK, which funded the research, said: "It's clear that we need to move away from the current one-size-fits-all approach to much more targeted treatment methods.

"The results from this study and others like it are crucial as they give an important understanding of the factors that drive certain prostate cancers, or make them vulnerable to specific treatments."

Last week scientists from Queen Mary University of London discovered a blood test that detects aggressive forms of prostate cancer that can identify patients with a ten times higher risk of dying from the disease.

We pay for your stories! Do you have a story for The Sun Online news team? Email us at tips@the-sun.co.uk or call 0207 782 4368

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analysis of article text


prohibitionist hits:0 government drug warrior (prohibition_agency) hits:0 propaganda (drugwar_propaganda) hits:54 legalization hits:0 drug_reformer hits:0 reform_referenda hits:0 cannabis hits:0 stimulant hits:0 narcotic hits:0 hallucinogen hits:0
    prohibitionist     prohibition_agency     drugwar_propaganda     legalization     drug_reformer
    reform_referenda     cannabis     stimulant     narcotic     hallucinogen
                        
                        


incarceration/prison mentioned? NO - the issue of prison or incarceration was NOT mentioned in this article .

propaganda analysis


explicit prohibition propaganda (explicit_propaganda) hits:0 hated group (propaganda_theme1) hits:4 madness, violence, illness (propaganda_theme2) hits:45 survival of society (propaganda_theme3) hits:0 gateway, use is abuse (propaganda_theme4) hits:1 children (propaganda_theme5) hits:4 demonize, war, epidemic (propaganda_theme6) hits:0 total prohibition (propaganda_theme7) hits:0 dissent opposed (propaganda_theme8) hits:0
EXP - explicit prohibition propaganda (explicit_propaganda) GRP - hated group (propaganda_theme1) MAD - madness, violence, illness (propaganda_theme2)
SOC - survival of society (propaganda_theme3) USE - gateway, use is abuse (propaganda_theme4) KID - children (propaganda_theme5)
WAR - demonize, war, epidemic (propaganda_theme6) TOT - total prohibition (propaganda_theme7) DIS - dissent opposed (propaganda_theme8)



conceptevidencehitslinks
 drug of abuse implied / mentioned

drug related 60%
[news] [concept]

illegal drugs  
drugwar_propaganda : a drug war propaganda event, campaign release, slogan, or themepropaganda

drugwar propaganda 80%
[news] [concept]

propaganda theme1 propaganda theme2 propaganda theme5 propaganda theme4 Why Are Americans So Easy to Manipulate? (Bruce E Levine, 2012)
Classic Modern Drug Propaganda
Themes in Chemical Prohibition
Drug War Propaganda (kindle edition)
propaganda_theme1 : drug war propaganda theme: hated groupshated group

propaganda theme1 55%
[news] [concept]

"terror"4Hated Groups (propaganda theme 1)
drugwarfacts.org/druguse.htm
drugwarfacts.org/racepris.htm
America's Racist Drug laws
narcoterror.org/
Labeling theory
Transfer (propaganda)
 addiction 60%
[news] [concept]
"addiction"1Twelve-Step Snake Oil (2012)
Ceremonial Chemistry: The Ritual Persecution of Drugs, Addicts, and Pushers (Thomas Szasz)
Rat Park
substance.com/stop-nora-volkow-l...
iboga-experience.nl/
lewrockwell.com/2013/08/stephen-...
wakingtimes.com/2014/03/12/canna...
Most People With Addiction Simply Grow Out of It: Why Is This Widely Denied? (2014)
propaganda_theme2 : drug war propaganda theme: madness, violence, illness caused by drugsmadness, violence, illness

propaganda theme2 80%
[news] [concept]

"deadly" "FATAL" "anxiety" "cancerJump" "CANCER" "cancers" "problems" "health problems" "stroke" "disease" "nightmares" "horror" addiction44Madness Crime Violence Illness (propaganda theme 2)
drugwarfacts.org/crime.htm
drugwarfacts.org/causes.htm
Distortion 18: Cannabis and Mental Illness
No, marijuana use doesn't lower your IQ (10/2014)
 use is abuse

use is abuse 60%
[news] [concept]

"taking drugs"1Use is Abuse (propaganda theme 4)
drugwarfacts.org/addictiv.htm
propaganda_theme4 : drug war propaganda theme: all use is abuse, gatewaygateway, use is abuse

propaganda theme4 60%
[news] [concept]

use is abuse Use is Abuse, Gateway (propaganda theme 4)
propaganda_theme5 : drug war propaganda theme: children corrupted by drugschildren

propaganda theme5 60%
[news] [concept]

"child" "kids" "baby"4Children Corrupted (propaganda theme 5)
drugwarfacts.org/adolesce.htm
Think of the children
 drug of abuse

illegal drugs 60%
[news] [concept]

various illegal drugs addiction  
 drugs 95%
[news] [concept]
various drugs  
 various drugs 95%
[news] [concept]
"drug" "drugs"12 
 various illegal drugs 50%
[news] [concept]
"drug problems" "taking drugs"2mapinc.org
drugwarfacts.org
DEA's Drugs of Abuse booklet
drugwarfacts.org/drugtest.htm
 youth 60%
[news] [concept]
propaganda theme5 ssdp.org/
mapinc.org/youth.htm
 school
[news] [concept]
"University"1ssdp.org/

re:0.49 st:0.01 fo:0 s:0 d:0.02 c:0 db:0.621 a:0.6 m:0.25 t:2.46 (f)


text of article used for CRITICAL ANALYSIS, under FAIR USE provisions of the Copyright Act of 1976, 17 U.S.C. § 107, et al.


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    article tags



     

    school concept
    youth concept
    various_illegal_drugs concept - general terms for illegal drugs
    various_drugs concept - general terms for drugs
    drugs concept
    illegal_drugs concept - drugs of abuse, so-called
    propaganda_theme5 concept - drug war propaganda theme: children corrupted by drugs
    propaganda_theme5
    propaganda_theme4 concept - drug war propaganda theme: all use is abuse, gateway
    propaganda_theme4
    use_is_abuse concept - drug war propaganda theme: all use is abuse
    propaganda_theme2 concept - drug war propaganda theme: madness, violence, illness caused by drugs
    propaganda_theme2
    addiction concept - addition or drug dependency
    propaganda_theme1 concept - drug war propaganda theme: hated groups
    propaganda_theme1
    drugwar_propaganda concept - a drug war propaganda event, campaign release, slogan, or theme
    drugwar_propaganda
    drug_related concept - related to illegal drugs and prohibition