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US: Radnor-based Narcan maker earns shout-out from Trump and surgeon general - Philly

Found: Tue Apr 17 14:04:54 2018 PDT
Source: Philadelphia Daily News (PA)
Copyright: 2018 Philadelphia Newspapers Inc.
Source: Philadelphia Inquirer, The (PA)
Copyright: 2018 Philadelphia Newspapers Inc
Webpage: [translate]
Author: Erin Arvedlund, Inquirer Staff Writer

topical analysis
prison was NOT mentioned
propaganda analysis

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Radnor-based Narcan maker earns shout-out from Trump and surgeon general Updated: April 16, 2018 -- 12:15 PM EDT

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Cameron HartHarm Reduction Coordinator Allison Herens administers a Narcan nasal spray to a test dummy during an opioid public awareness campaign at the Philadelphia Department of Public Health in Center City on Thursday, March 15, 2018. This nasal spray needs no assembly and can be sprayed in one nostril by pushing a plunger. ( CAMERON HART / For the Inquirer )

Erin Arvedlund

Inquirer Staff Writer

Erin Arvedlund writes a weekly column for the Inquirer on investing and personal finance. Her first book was Too Good to Be True: The Rise and Fall of Bernie Madoff (Penguin).

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Every day, 115 people drop dead due to opioid overdoses - about half from prescription drugs and the rest from illicit drug use. So what if Narcan - a nasal-spray antidote to opioid overdose - becomes as widely available as flu shots?




That's the hope of Radnor-based Adapt Pharma, which recently got a shout-out from President Trump and backing from the surgeon general.

"We're trying to make sure first responders, hospitals, universities all have access to our Narcan nasal spray," Seamus Mulligan, founder and CEO, said in an interview from Dublin, his native country and site of the company's world headquarters. Mulligan splits his time between Ireland, his native country, and Radnor, where Adapt Pharma has its U.S. headquarters.

Other drug companies also make naloxone, the drug used in Narcan nasal spray. Those companies include Kaleo and Amphastar Pharmaceuticals. Naloxone can be administered by non-medically trained people using two versions approved by the Food and Drug Administration: Narcan Nasal Spray and Evzio, an auto-injector. Narcan Nasal Spray is the leading product in units distributed, Adapt executives said, in part because it's easier for nonmedical folks to use than injectables.

Like many drugs, cost has been a sore point.

"We dealt with a number of patient groups and the governmental agencies, and we know price is an issue," Mulligan noted.

Currently, Narcan is available without a prescription at any participating pharmacy - at a retail cost of $125 for two doses. In response to the epidemic, Adapt prices Narcan 40 percent lower for nonprofits, first responders, schools, and any government agency, which pays $75 for two doses, or $37.50 a dose. Narcan Nasal Spray's list price hasn't changed since then.

Mulligan is a longtime Philadelphia drug company executive. He founded Azur Pharma, which was acquired by Jazz Pharmaceuticals of California in 2011. Then, in 2013, he took the money he earned from that acquisition to start Adapt Pharma in Radnor.

Adapt Pharma

Adapt Pharma founder and CEO Seamus Mulligan. The Irish company, which makes Narcan nasal spray, has U.S. headquarters in Radnor.

"One of our first projects was a nasal formulation of naloxone," Mulligan said. "We took over a development program [of nasal spray] from Opiant, and we completed the development and had it out in 14 weeks. We got fast-tracked and got priority review with the FDA" in November 2015. The product Narcan launched in 2016. Narcan is a brand name for Adapt's nasal spray of naloxone.

"Part of the additional value we brought was we're quick to recognize the need," he said. "We also applied for the trademark - that was the key value-add. In addition, we're spreading the message of awareness, access, and affordability. The brand name gave us a start on awareness, and at a price point that's affordable. There's also 95 percent insurance coverage, and the average co-pay for 74 percent of people is less than $10. We work to ensure affordability."

Adapt Pharma is private and doesn't release revenues or profit projections, but last year the company shipped one million cartons (each carton contains two doses) and in the first quarter of 2018 shipped 375,000 cartons, or 750,000 doses, Maguire said. Narcan holds just more than 80 percent share of the retail market, and the total market ranges between $100 million and $150 million.

Adapt licensed the nasal-spray version from Opiant in exchange for royalty fees. And that FDA-approved spray delivery system is key.

"Not many people want to inject other people," Roger Crystal, CEO of Opiant, told the Associated Press. "Once you have a nasal spray, you open up a huge patient population and bystander population who are now willing and able to use it. ... Police officers in certain counties [hold] up Narcan like a trophy. They're proud. They're empowered. They can do something about an overdose rather than arriving to a cold body."

What's the potential market? According to the Centers for Disease Control and Prevention, 60 million people in the United States were prescribed opioids in 2017. Of those, 20 million people were prescribed high-dose opioids, or greater than 50 MME (morphine milligram equivalent). The CDC recommends patients prescribed 50 MME should receive a co-prescription of naloxone to prevent overdose.

Will Adapt one day go public? "Our focus at this moment is trying to maximize awareness and distribution of Narcan Nasal Spray across the U.S. and Canada," Mulligan said.

Currently, the company doesn't need capital. Mulligan and other management contributed $115 million of their own money to start the company.

"We believe fervently in this, and the benefit is that it gives us control," he said. "We don't have to look to a VC or private equity fund."

How did Adapt Pharma end up in Philadelphia? Adapt's chief operating office, Eunan Maguire, and other Adapt executives worked here with prior drug companies; Maguire worked with Azur and lived in Center City from 2007 to 2012.

"We really like the area," Maguire said. "Philly is just very pro-business. Jazz is testament to what a start-up company can become." Since Adapt is based in Radnor, home to drug giants such as Wyeth and Pfizer, "there's a great network of talent here. As mid- and large-sized companies move here, we're tapping into that talent."

In total, Adapt employs roughly 50 people, 30 in the U.S. and the remainder in Dublin, where finance, R&D, and management executives are based. Adapt has other drugs in the pipeline, including very early-stage drugs to treat addiction rather than overdose, Maguire said.

Adapt faces stiff competition on many fronts, including competitors developing new products. Adapt sued Teva Pharmaceuticals USA in federal court in New Jersey in 2016, saying Teva's application to sell a generic version of Adapt's Narcan nasal-spray treatment for opioid overdoses infringes on the drug's patent. The suit is ongoing.

And it helps when the U.S. president speaks up for your product. U.S. Surgeon General Jerome Adams added his voice in early April: "Each day we lose ... one person every 12.5 minutes," he said. Although Adams didn't name the brand Narcan, he did urge Americans to carry naloxone. "It is time to make sure more people have access to this lifesaving medication, because 77 percent of opioid overdose deaths occur outside of a medical setting, and more than half occur at home."

Adapt is now looking to diversify. "We have a pipeline of overdose treatments and early-stage treatment programs we're starting to bring through," Maguire said. "But in the U.S., they have to ensure affordable access through agencies such as Medicaid, Medicare, and commercial insurance. Secondly, availability: Naloxone is a prescription drug, but you can also walk into a pharmacy and buy it without a prescription from a doctor. We're trying to get that message out through retailers such as Walgreens, Rite Aid, and CVS, which carry Narcan in stores."

Insurers such as Independence Blue Cross said this year that its clients will have access to Narcan without charge. CVS last week said it would sell Narcan for $95 for those without insurance.

Narcan and other forms of naloxone are not a cure-all. It often must be administered multiple times and sometimes fails to revive the person who overdoses. But public health advocates have embraced it as a key weapon.

"We think this is the right medication to have if there are opioids in the home, people who are potential witnesses or first responders to overdoses," Maguire said. "In the state of Pennsylvania, the state and city police carry Narcan," and other states are beginning to follow suit.

Manuel Balce Ceneta

Surgeon General Jerome Adams speaks during a National African American History Month reception hosted by President Trump and first lady Melania Trump. The nation's chief doctor wants more Americans to start carrying the overdose antidote naloxone in an effort to combat the nation's opioid crisis.

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analysis of article text

prohibitionist hits:0 government drug warrior (prohibition_agency) hits:0 propaganda (drugwar_propaganda) hits:32 legalization hits:0 drug_reformer hits:0 reform_referenda hits:0 cannabis hits:3 stimulant hits:0 narcotic hits:11 hallucinogen hits:0
    prohibitionist     prohibition_agency     drugwar_propaganda     legalization     drug_reformer
    reform_referenda     cannabis     stimulant     narcotic     hallucinogen

incarceration/prison mentioned? NO - the issue of prison or incarceration was NOT mentioned in this article .

propaganda analysis

explicit prohibition propaganda (explicit_propaganda) hits:0 hated group (propaganda_theme1) hits:2 madness, violence, illness (propaganda_theme2) hits:16 survival of society (propaganda_theme3) hits:9 gateway, use is abuse (propaganda_theme4) hits:3 children (propaganda_theme5) hits:0 demonize, war, epidemic (propaganda_theme6) hits:2 total prohibition (propaganda_theme7) hits:0 dissent opposed (propaganda_theme8) hits:0
EXP - explicit prohibition propaganda (explicit_propaganda) GRP - hated group (propaganda_theme1) MAD - madness, violence, illness (propaganda_theme2)
SOC - survival of society (propaganda_theme3) USE - gateway, use is abuse (propaganda_theme4) KID - children (propaganda_theme5)
WAR - demonize, war, epidemic (propaganda_theme6) TOT - total prohibition (propaganda_theme7) DIS - dissent opposed (propaganda_theme8)

 drug of abuse implied / mentioned

drug related
[news] [concept]

illegal drugs  
drugwar_propaganda : a drug war propaganda event, campaign release, slogan, or themepropaganda

drugwar propaganda 90%
[news] [concept]

propaganda theme1 propaganda theme2 propaganda theme3 propaganda theme6 propaganda theme4 Why Are Americans So Easy to Manipulate? (Bruce E Levine, 2012)
Classic Modern Drug Propaganda
Themes in Chemical Prohibition
Drug War Propaganda (kindle edition)
propaganda_theme1 : drug war propaganda theme: hated groupshated group

propaganda theme1 90%
[news] [concept]

"Racial" "African American"2Hated Groups (propaganda theme 1)
America's Racist Drug laws
Labeling theory
Transfer (propaganda)
 addiction 60%
[news] [concept]
"addiction"2Twelve-Step Snake Oil (2012)
Ceremonial Chemistry: The Ritual Persecution of Drugs, Addicts, and Pushers (Thomas Szasz)
Rat Park
Most People With Addiction Simply Grow Out of It: Why Is This Widely Denied? (2014)
propaganda_theme2 : drug war propaganda theme: madness, violence, illness caused by drugsmadness, violence, illness

propaganda theme2 75%
[news] [concept]

"overdoses" "overdose" "deaths" "problems" "Disease" addiction14Madness Crime Violence Illness (propaganda theme 2)
Distortion 18: Cannabis and Mental Illness
No, marijuana use doesn't lower your IQ (10/2014)
propaganda_theme3 : drug war propaganda theme: survival of societysurvival of society

propaganda theme3 75%
[news] [concept]

"Americans" "American" "Public Health" "The nation" "The nation's"9Survival of Society (propaganda theme 3)
The "Nation" as a Device To Create a Psychological Crowd
 use is abuse

use is abuse 60%
[news] [concept]

"drug use" "drug used" "Abuse"3Use is Abuse (propaganda theme 4)
propaganda_theme4 : drug war propaganda theme: all use is abuse, gatewaygateway, use is abuse

propaganda theme4 60%
[news] [concept]

use is abuse Use is Abuse, Gateway (propaganda theme 4)
propaganda_theme6 : drug war propaganda theme: demonize; use of drugs is epidemic; wardemonize, war, epidemic

propaganda theme6 65%
[news] [concept]

"epidemic" "combat"2Demonize, War (propaganda theme 6)
List of Wars on Concepts
Perpetual war
The Failed War on Drugs (2012)
 drug of abuse

illegal drugs
[news] [concept]

cannabis various illegal drugs addiction narcotic  
[news] [concept]
various drugs  
 psychoactive chemical

[news] [concept]

 psychoactive plant

[news] [concept]

 psychoactive pharmaceutical

[news] [concept]

morphine naloxone
 opioid narcotic analgesic
[news] [concept]
 euphoric depressant
[news] [concept]
[news] [concept]
[news] [concept]
opioid : opiate-like but synthetic drugsopioid

[news] [concept]

"opioid" "opioids"10Managing Pain
[news] [concept]
opioid opiate Managing Pain
opiate : a substance derived from the opium poppyopiate
[news] [concept]
morphine Managing Pain
 naloxone - opioid overdose antidote

[news] [concept]

"Narcan" "naloxone" injection.html
cannabis : cannabis (marijuana) product or usecannabis
[news] [concept]
"marijuana" "cannabis" cannabis industry2Cannabis: Religious and Spiritual Uses
Cannabis-Driving Studies Cannabis Link DB
Schaffer Library: Marijuana
U.S. Prisons Thriving on Jim Crow Marijuana Arrests (2013)
 cannabis industry 55%
[news] [concept]
"equity fund"1https://www.newcannabisventures....

[news] [concept]

 various drugs
[news] [concept]
"Pharmaceuticals" "drugs" "drug"20 
 various illegal drugs
[news] [concept]
"illicit drug" "prescription drugs"
DEA's Drugs of Abuse booklet
[news] [concept]
 mainstream (controlled) media

[news] [concept]

mockingbird Mainstream Media
Michael Levine, Mainstream Media: The Drug War Shills
Mainstream Media: The Most Significant Threat To Freedom
 Mockingbird / Wurlitzer; US intel-controlled media

[news] [concept]

assoc press Operation Mockingbird - Mighty Wurlitzer cia a...
US Media Conceals News (2013)
Two of the Largest American Newspapers Opine in Favor of Allowing States to Legalize Marijuana (2012)
Propaganda 101: Operation Mockingbird Continues (2015)
 assoc press
[news] [concept]
"Associated Press" cia a...
Associated Press (AP) - Mockingbird / Wurlitzer

st:0.01 fo:0 s:0.01 d:0 c:0.03 db:0.165 a:0.77 m:0.52 t:1.81 (f)

text of article used for CRITICAL ANALYSIS, under FAIR USE provisions of the Copyright Act of 1976, 17 U.S.C. § 107, et al.

media charts

Bot's analysis of: "The Dangers and Consequences of Marijuana Abuse" the U.S. Department of Justice Drug Enforcement Administration (DEA) Demand Reduction Section, May 2014
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    article tags


    assoc_press concept - AP - Associated Press - long linked with "Mighty Wurlitzer" intel ops like, "Operation Mockingbird"
    mockingbird concept - documented US intel controlled media: newspapers, tv, radio - various press associated with known intel ops such as, "Operation Mockingbird", "Mighty Wurlitzer", etc.
    msm concept - mainstream media - corporate, government controlled press: newspaper, tv, radio, websites; press associated with known intel ops such as, "Operation Mockingbird", "Mighty Wurlitzer", Tavistock Institute, etc.
    school concept
    various_illegal_drugs concept - general terms for illegal drugs
    various_drugs concept - general terms for drugs
    morphine concept - Morphine is an opiate used in the treatment of severe pain. It occurs naturally in the opium poppy and has a long history of human use. ((5a,6a)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol)
    cannabis_industry concept - cannabis industry - (emerging) marijuana, cannabis industries; marijuana businesses; stock market marijuana plays; pot venture capital
    cannabis concept - cannabis (marijuana) product or use
    naloxone concept - naloxone hydrochloride is an opioid antagonist which prevents or reverses the effects of opioids
    opiate concept - a substance derived from the opium poppy
    narcotic concept - a drug that dulls senses, relieves pain, induces sleep
    opioid concept - opiate-like but synthetic drugs
    intoxicant concept
    analgesic concept
    euphoric_depressant concept
    opioid_narcotic_analgesic concept
    pharms concept - Psychoactive Pharmaceuticals are over-the-counter or prescription chemicals approved for human medicinal use, with mind- or emotion-altering properties
    plants concept - Plants listed in this section are those which have been used by humans for their mind- or emotion-altering properties.
    chemicals concept - Psychoactive Chemicals are chemicals which have mind- or emotion-altering properties.
    drugs concept
    illegal_drugs concept - drugs of abuse, so-called
    propaganda_theme6 concept - drug war propaganda theme: demonize; use of drugs is epidemic; war
    propaganda_theme4 concept - drug war propaganda theme: all use is abuse, gateway
    use_is_abuse concept - drug war propaganda theme: all use is abuse
    propaganda_theme3 concept - drug war propaganda theme: survival of society
    propaganda_theme2 concept - drug war propaganda theme: madness, violence, illness caused by drugs
    addiction concept - addition or drug dependency
    propaganda_theme1 concept - drug war propaganda theme: hated groups
    drugwar_propaganda concept - a drug war propaganda event, campaign release, slogan, or theme
    drug_related concept - related to illegal drugs and prohibition