Bot  

search:

fast-breaking news analysis about drug policy and illegal drugs

Your Enslavement in the Matrix
five star (video)

Prison for Profit
The Rise of the Prison Industrial Complex
Prison Profiteers (2013)


Here

home   about

MAP scholar

propaganda news

canada uk

australia pot news

psychedelics news

tag cloud topics

concept dictionary

feeds   stats

user analysis

contact us   faq   chat

login register


Mapinc

news hawking!

latest

drugnews

DrugSense

A Drug War Carol

No Victim/No Crime - fija.org

FREE NJWEEDMAN
2017 FREE NJWEEDMAN
May 3, 2017 - please help Ed Forchion


Need facts? See: DrugWarFacts.org

this bot site is Hosted By DrugPolicyCentral! ... Please help us keep going!

Cannabinoid Receptor Agonists May Be Novel Class of Anti-Lymphoma Agents

Cannabinoid Receptor Agonists May Be Novel Class of Anti-Lymphoma Agents

By Faith Reidenbach

NEW YORK (Reuters Health) Jul 25 - Delta-9-tetrahydrocannibinol (THC), the major component of marijuana, and other cannabinoids induce apoptosis in murine tumors of immune origin, according to researchers at Virginia Commonwealth University in Richmond.

Like other immune cells, cancers of the immune system express a cannabinoid receptor known as CB2, Dr. Mitzi Nagarkatti explained in an interview with Reuters Health. Compounds that bind CB2 receptors selectively induce apoptosis in these cancer cells, she said. Moreover, "compounds that interact with CB2 will not exhibit psychotropic effects."

In a series of in vitro experiments, Dr. Nagarkatti and her colleagues exposed murine lymphoma and mastocytoma cells to four cannabinoid receptor agonists. THC and two of the others significantly reduced cell viability and increased apoptosis, they report in the July 15th issue of Blood.

In vivo experiments confirmed the effect of THC. Ten days after mice were injected with lymphoma cells, cells collected from animals treated with the highest dose of THC showed 77.3% apoptosis. Two weeks of THC treatment cured 25% of lymphoma-bearing mice.

"It is possible that the immunosuppressive effects of THC may have interfered with the host's antitumor immunity, which may account for a lower percentage of cures," the researchers comment. They are currently conducting murine dose-ranging studies.

The research group also demonstrated that three human leukemia and lymphoma cell lines expressed CB2 and not CB1. Three cannabinoids, including THC, induced apoptosis in these cell lines in vitro, and THC showed the same effect when cultured with cells from patients diagnosed with acute lymphoblastic leukemia.

"Recently, however, we identified a human cell line that was resistant," Dr. Nagarkatti's team reports. "Further studies are in progress to address whether this cell line lacks physical or functional cannabinoid receptors and/or signaling molecules that trigger apoptosis."

In addition, the research team is currently "screening a large number of CB2 analogs to identify compounds that are highly efficacious in killing the cancer cells," Dr. Nagarkatti said. "We are also investigating whether endogenous cannabinoids can exert antitumor activity."

Blood 2002;100:627-634.

media charts

Bot's analysis of: "The Dangers and Consequences of Marijuana Abuse" the U.S. Department of Justice Drug Enforcement Administration (DEA) Demand Reduction Section, May 2014
more >>


Newsbot crossword puzzles!

Drug War
Propaganda

A review and analysis of modern prohibition rhetoric

  • Amazon Kindle
  • html (free)
  • pdf (free)
  •   Wonder Drug Cover-Up: Yes, it's true: pot fights cancer. more

    As Bad For Your Lungs As Smoking 20 Normal Cigarettes? 20 times more likely to cause cancer than tobacco? Why does the US Government make cannabis researchers use only Government-issued marijuana?

     
     

    Observer's Propaganda Picks
    dripping with drug-war propaganda!


    Prohibition-era cartoons
    Anti-prohibition political cartoons from Prohibition I.

     
      Support Mapinc & Drugsense

    Donate to drugsense please give generously!